. We want to shed light on what really works for urinary health.
The nutritional supplement industry is completely unregulated
and often, claims about products are very misleading.
"As physicians, we wanted to make the highest quality and most transparent
products available so we could feel
100% confident recommending them to our patients."
Many consumers are unaware that cranberries alone or cranberry extracts
do not containnearly the amount of the active ingredient: A2 type proanthocyanidins.
It’s the PACs, within cranberries, that are clinically proven to prevent UTIs and protect bladder health. Many cheaper brands use green tea or grape seed extract to derive their PAC's, but these do not contain the effective levels of the A2 type PAC's.
The A2 PAC's have an anti-adhesion effect, which keeps bacteria from sticking to the urethra and bladder walls - 36mg type A2 PAC's have been specifically shown to be the required dose to be effective.
1 dose of UTRx has up to 250x more PAC’s than some other cranberry supplements.
When UTRx reaches you, it has been tested and validated 3 separate times
by 2 independent labs.
Very few nutritional supplement companies follow this rigorous testing protocol to ensure the highest quality.
(1) In a prospective trial of 308 women using daily antibiotic (Nitrofurantoin ) versus D-mannose versus placebo, D-mannose powder had significantly reduced the risk of recurrent UTI which was no different than in Nitrofurantoin group - Kranjcec B, Papes D, Altarac S: D-mannose
powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol 2014;32:79.
(2) In Randomized Trial of women with recurrent UTI's, patient's were assigned to antibiotic treatment with trimethoprim/sulfamethoxazole or to a regimen of oral D-mannose . D-mannose appeared to be a safe and effective treatment for recurrent UTIs in adult women. A significant difference was observed in the proportion of women remaining infection free versus antibiotic treatment.
- Porru D, Parmigiani A, Tinelli C et al: Oral D-mannose in recurrent urinary tract infections in women: A pilot study. J Clin Urol 2014;7:208.
(3) Cranberry prophylaxis is now recommended by the 2019 American Urological Associations (AUA) Guidelines on Recurrent Uncomplicated Urinary Tract Infections in Women
- Clinicians may offer cranberry prophylaxis for women with rUTIs. (Conditional Recommendation)
(4) In a Systematic Review of 5 Randomized Clinical Trials (RCTs) that studied cranberry in tablets/capsules/beverage form found that cranberry was associated with decreased risk of experiencing at least 1 UTI recurrence than placebo or no cranberry (5 trials, RR 0.67, 95% CI 0.54 to 0.83 ARD -11%, 95%CI -16% to 5%).
(5) Maki KC, Kaspar KL, Khoo C et al: Consumption of a cranberry juice beverage lowered the number of clinical urinary tract infection episodes in women with a recent history of urinary tract infection. Am J Clin Nutr 2016; 103:1434.
(6) Stothers L: A randomized trial to evaluate effectiveness and cost effectiveness of naturopathic cranberry products as prophylaxis against urinary tract infection in women. Can J Urol 2002;9:1558
(7) Takahashi S, Hamasuna R, Yasuda M et al: A randomized clinical trial to evaluate the preventive effect of cranberry juice (UR65) for patients with recurrent urinary tract infection. J Infect Chemother 2013;19:112.
(8)Vostalova J, Vidlar A, Simanek V et al: Are high proanthocyanidins key to cranberry efficacy in the prevention of recurrent urinary tract infection? Phytother Res 2015;29:1559
(9)Walker EB, Barney DP, Mickelsen JN et al: Cranberry concentrate: UTI prophylaxis. J Fam Pract 1997;45:167.
(10) In young women, using Vitamin C was found to be associated with a decreased UTI risk and protect against UTI's (no prior UTI: OR 0.59; 95% CI, 0.35–0.98; one or more prior UTIs: OR 0.85; 95% CI, 0.58–1.25].
- Foxman B, Chi JW. Health behavior and urinary tract infection in college-aged women. J Clin Epidemiol. 1990;43:329–337.
(11) In a Randomized Trial of pregnant women treated with preventative dietary supplements of ferrous sulfate, folic acid, Vitamin C (Ascorbic Acid), At 3 months, the presence of urinary infections in the ascorbic acid-treated group was significantly lower than in the ferrous sulfate and folic acid only group (OR 0.35; CI 95%, 0.13–0.91).
- Ochoa-Brust GJ, Fernández AR, Villanueva-Ruiz GJ, et al. Daily intake of 100 mg ascorbic acid as urinary tract infection prophylactic agent during pregnancy. Acta Obstet Gynecol Scand. 2007;86:783–787.
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