(1) In a prospective trial of 308 women using daily antibiotic (Nitrofurantoin ) versus D-mannose versus placebo, D-mannose powder had significantly reduced the risk of recurrent UTI which was no different than in Nitrofurantoin group - Kranjcec B, Papes D, Altarac S: D-mannose
powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol 2014;32:79.
(2) In Randomized Trial of women with recurrent UTI's, patient's were assigned to antibiotic treatment with trimethoprim/sulfamethoxazole or to a regimen of oral D-mannose . D-mannose appeared to be a safe and effective treatment for recurrent UTIs in adult women. A significant difference was observed in the proportion of women remaining infection free versus antibiotic treatment.
- Porru D, Parmigiani A, Tinelli C et al: Oral D-mannose in recurrent urinary tract infections in women: A pilot study. J Clin Urol 2014;7:208.
(3) Cranberry prophylaxis is now recommended by the 2019 American Urological Associations (AUA) Guidelines on Recurrent Uncomplicated Urinary Tract Infections in Women
- Clinicians may offer cranberry prophylaxis for women with rUTIs. (Conditional Recommendation)
(4) In a Systematic Review of 5 Randomized Clinical Trials (RCTs) that studied cranberry in tablets/capsules/beverage form found that cranberry was associated with decreased risk of experiencing at least 1 UTI recurrence than placebo or no cranberry (5 trials, RR 0.67, 95% CI 0.54 to 0.83 ARD -11%, 95%CI -16% to 5%).
(5) Maki KC, Kaspar KL, Khoo C et al: Consumption of a cranberry juice beverage lowered the number of clinical urinary tract infection episodes in women with a recent history of urinary tract infection. Am J Clin Nutr 2016; 103:1434.
(6) Stothers L: A randomized trial to evaluate effectiveness and cost effectiveness of naturopathic cranberry products as prophylaxis against urinary tract infection in women. Can J Urol 2002;9:1558
(7) Takahashi S, Hamasuna R, Yasuda M et al: A randomized clinical trial to evaluate the preventive effect of cranberry juice (UR65) for patients with recurrent urinary tract infection. J Infect Chemother 2013;19:112.
(8)Vostalova J, Vidlar A, Simanek V et al: Are high proanthocyanidins key to cranberry efficacy in the prevention of recurrent urinary tract infection? Phytother Res 2015;29:1559
(9)Walker EB, Barney DP, Mickelsen JN et al: Cranberry concentrate: UTI prophylaxis. J Fam Pract 1997;45:167.
(10) In young women, using Vitamin C was found to be associated with a decreased UTI risk and protect against UTI's (no prior UTI: OR 0.59; 95% CI, 0.35–0.98; one or more prior UTIs: OR 0.85; 95% CI, 0.58–1.25].
- Foxman B, Chi JW. Health behavior and urinary tract infection in college-aged women. J Clin Epidemiol. 1990;43:329–337.
(11) In a Randomized Trial of pregnant women treated with preventative dietary supplements of ferrous sulfate, folic acid, Vitamin C (Ascorbic Acid), At 3 months, the presence of urinary infections in the ascorbic acid-treated group was significantly lower than in the ferrous sulfate and folic acid only group (OR 0.35; CI 95%, 0.13–0.91).
- Ochoa-Brust GJ, Fernández AR, Villanueva-Ruiz GJ, et al. Daily intake of 100 mg ascorbic acid as urinary tract infection prophylactic agent during pregnancy. Acta Obstet Gynecol Scand. 2007;86:783–787.